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Research ARTICLEcrossmarkRequirements for Carnitine Shuttle-Mediated Translocation of Mitochondrial Acetyl Moieties to the Yeast CytosolHarmen M. van Rossum,* Barbara U. Kozak,* Matthijs S. Niemeijer, James C. Dykstra, Marijke A. H. Luttik, Antonius J. A. van Maris, Jack T. PronkDepartment of Biotechnology, Delft University of Technology, Delft, The Netherlands* Present address: Harmen M. van Rossum, Zymergen, Emeryville, California, USA; Barbara U. Kozak, Dupont, Leiden, The Netherlands.Jean-Marc G. Daran,ABSTRACT In a lot of eukaryotes, the carnitine shuttle plays a essential part in intracellular transport of acyl moieties. Fatty acidgrown Saccharomyces cerevisiae cells employ this shuttle to translocate acetyl units into their mitochondria. Mechanistically, the carn.
