Product Name :
NOX2/gp91phox Rabbit Polyclonal Antibody
Predicted band size :
Observed band size :
Synonyms:
AMCBX2 antibody CGD antibody CGD91-phox antibody CY24B_HUMAN antibody CYBB antibody Cytochrome b 245, beta polypeptide antibody Cytochrome b(558) beta chain antibody Cytochrome b(558) subunit beta antibody Cytochrome b-245 heavy chain antibody Cytochrome b558 subunit beta antibody 展开
Function :
Mox1 and the glycoprotein gp91-phox are largely related proteins that are essential components of the NADPH oxidase. The superoxide-generating NADPH oxidase is present in phagocytes, neuroepithelial bodies, vascular smooth muscle cells and endothelial cells. It includes a membrane-bound flavocytochrome containing two subunits, gp91-phox and p22-phox, and the cytosolic proteins p47-phox and p67-phox. The p22- and gp91-phox subunits also function as surface O2 sensors that initiate cellular signaling in response to hypoxic conditions. Mox1 and gp91 contain identical C-terminal sequence identity, yet they have distinct expression patterns. gp91-phox is expressed in eosinophils, neutro-phils, monocytes and B-lymphocytes, whereas Mox1 is predominantly detected in the colon, and low expression is also detected in the uterus and prostate. Mox1 is also upregulated in vascular smooth-muscle cells in response to PDGF stimulation, which collectively indicates that Mox1 may function analogously to gp91-phox, yet regulate the NADPH superoxide production in non-phagocytic cells.Phosphatidylcholines,soya custom synthesis
Antibody Type:
Rabbit Polyclonal Antibody
Immunogen :
Synthetic peptide corresponding to C-terminal human NOX2/gp91phox.Ethyl 2-oxo-2-(2-oxocyclohexyl)acetate In stock
Species reactivity:
Human, Mouse
Verify application:
IF-Cell, IHC-P, FC
Coupling :
unconjugated
Clone number:
RRID:
AB_3069031
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing.PMID:33568038 Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
Storage buffer solution:
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG
Purification method :
Immunogen affinity purified.
ELTSA :
Molecular weight :
Predicted band size: 65 kDa
Positive control :
HepG2, MCF-7, Hela, human liver tissue, human spleen tissue, human tonsil tissue, mouse spleen tissue.